منابع مشابه
Neurotoxicity of tryptophan metabolites.
The metabolism of tryptophan by the kynurenine pathway leads to the production of several neurotoxic compounds, some of which have been associated with neurological disorders. Recent investigation of some relevant compounds in this pathway has provided further evidence of their neurotoxicity.
متن کاملChromatographic analysis of tryptophan metabolites
The kynurenine pathway generates multiple tryptophan metabolites called collectively kynurenines and leads to formation of the enzyme cofactor nicotinamide adenine dinucleotide. The first step in this pathway is tryptophan degradation, initiated by the rate-limiting enzymes indoleamine 2,3-dioxygenase, or tryptophan 2,3-dioxygenase, depending on the tissue. The balanced kynurenine metabolism, w...
متن کاملTryptophan Metabolism in Rat Liver After Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitors
Rat liver tryptophan (Trp), kynurenine pathway metabolites, and enzymes deduced from product/substrate ratios were assessed following acute and/or chronic administration of kynurenic acid (KA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), Trp, and the kynureni-nase inhibitors benserazide (BSZ) and carbidopa (CBD). KA activated Trp 2,3-dioxygenase (TDO), possibly by increasing ...
متن کاملQuantitative determination of tryptophan metabolites (via kynurenine) in biologic fluids.
HE POSSIBILITY OF 1)ETERMINING QUANTITATIVF LY some products of tryptophan metabolism (1) has been examined previously by one of the authors. Paper chromatography was used as a tool for the separation of kynurenine, 3-hydroxykynurenine, anthranilic, 3-hydroxyanthranilic, kynurenic, and xanthurenic acids. The purpose of this paper is to report on the quantitative determination of these products ...
متن کاملMaternal tryptophan and kynurenine pathway metabolites and risk of preeclampsia.
OBJECTIVE To estimate the association of maternal plasma concentrations of tryptophan and six kynurenine pathway metabolites with the risk of preeclampsia. METHODS The study was based on a subsample of 2,936 pregnant women who delivered singleton neonates in the Norwegian Mother and Child Cohort Study in 2002-2003. Maternal blood plasma was obtained at approximately gestational week 18 and wa...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1997
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.117.10-11_657